内容摘要：JoEllen Zembruski-Ruple, while in the care of New York City’s renowned Memorial Sloan Kettering Cancer Center, swallowed the first three chemotherapy pills to treat her squamous cell carcinoma on Jan. 29, her family members said. They didn’t realize the drug could kill her.

JoEllen Zembruski-Ruple, while in the care of New York City’s renowned Memorial Sloan Kettering Cancer Center, swallowed the first three chemotherapy pills to treat her squamous cell carcinoma on Jan. 29, her family members said. They didn’t realize the drug could kill her.

. It’s one of the first studies to clearly map the brain activity behind semaglutide’s effects and separate the benefits from the side effects at the neuron level.“We are starting to understand how semaglutide works in the brain,” said Linda Engström Ruud, a researcher at the University of Gothenburg and supervisor for the project. “The better we understand this, the greater the opportunity we have to improve them.”

The significance of this research goes beyond weight loss alone. Because GLP-1 receptor agonists like semaglutide are now being tested for other uses—including treatment for addiction and—it’s critical to know how these drugs behave in the brain.As millions of people begin using these drugs for obesity and related conditions, understanding the basic biology behind them becomes even more essential. With this new information, scientists may soon be able to fine-tune treatments so they work faster, last longer, and produce fewer side effects.

Instead of asking patients to tolerate nausea or risk, doctors may one day offer targeted options that speak only to the brain’s hunger-control circuits. And the discovery of these

-positive neurons could be the key to making that future possible.

Note: The article above provided above byThe next waterfall on the road trip is the impressive Angel Falls, a 90-foot cascade surrounded by cliffs. It is well worth the one-mile hike in, especially since the next waterfall on the tour can be seen from the car.

Coos Canyon may be visible from the road, but you won't want to miss the chance to swim in its green-water swimming hole, which is surrounded by a canyon of smooth, curving rocks.Next is The Cataracts, a series of clear pools and small falls set in a narrow gorge, followed by Dunn Falls, one of the more popular and well-known falls in Maine. Dunn Falls has two main cascades—an upper and a lower—which can only be accessed via a nearly two-mile-long loop trail. It also boasts access to the

The final cascade in the Maine waterfall loop, the, returns you close to where you started, north of Snow Falls Gorge and the town of West Paris. These falls are fed by a rugged stretch of the Bear River, producing two impressive cascades up to 30 foot drops. The lovely gorge setting makes Screw Auger a popular place to visit in the summer.